发布人:     发布日期: 2020-11-30    浏览次数:

谭俊杰

南京农业大学高层次引进人才，教授，博士生导师                                           

地   址：南京农业大学第三实验楼二期309

邮   箱：tanjunjie@njau.edu.cn 

个人简介 

2009年毕业于湖南大学生物技术专业，并获得理学学士学位。2009至2015年硕博连读并获得湖南大学分析化学专业博士学位。2015至2020年，在德国马克思普朗克分子植物生理研究所从事博士后研究。主要从事新型精准基因编辑工具开发以及在作物遗传育种中的应用。创新性开发了兼具高效率、高精度以及高特异性的新型碱基编辑器，能够实现特定位点上单个碱基的精准替换, 为人类遗传疾病治疗以及作物精准育种提供了重要工具。以第一作者或通讯作者在Nature Communications，Molecular Plant, Plant Biotechnology Journal, Trends in Genetics 等本领域国际主流刊物上发表论文10篇，其中1篇入选ESI高被引论文, 获授权国家发明专利2件，包括美国发明专利1件，入选国家级青年人才项目、江苏省“双创”人才。

研究方向

1. 作物高效精准基因编辑系统开发和优化

针对目前基因编辑技术在作物编辑上存在效率、精准度、范围以及类型等方面的技术瓶颈，研发新型基因编辑技术或通过理性设计、效应子融合等优化现有主流基因编辑技术

2. 作物新种质创制

开发或利用定向进化技术，创制优异等位变异新种质并整合基因编辑、人工智能、合成生物学等，构建多基因高效聚合育种技术体系，聚合有益基因及优异等位变异，创制高产、优质、抗病虫和抗除草剂相结合的突破性种质

欢迎对基因编辑感兴趣的副教授、讲师、博后、博士硕士研究生加入本课题组，携手共进，砥砺前行！

论文发表 （* 共一作，# 共通讯）

1. Junjie Tan*, Joachim Forner*, Daniel Karcher，Ralph Bock. DNA base editing in nuclear and organellar genomes. Trends in Genetics, 2022, https://doi.org/10.1016/j.tig.2022.06.015. (Feature Review)
   

2. 赖昕彤，王柯岚，由雨欣，谭俊杰， 基于CRISPR/Cas系统的DNA碱基编辑研究进展，《生物技术通报》，2022, 38(6): 1-6. (特约综述)

3. Yanbiao Zhou* ^#, Shichong Xu*, Nan Jiang , Xinhui Zhao, Zhenan Bai, Jinling Liu, Wei Yao, Qianying Tang, Gui Xiao, Chao Lv, Kai Wang, Xiaochun Hu, Junjie Tan ^#, Yuanzhu Yang ^#，Engineering of rice varieties with enhanced resistances to both blast and bacterial blight diseases via CRISPR/Cas9. Plant Biotechnology Journal, 2022, 20:876-885.

4. Junjie Tan, Fei Zhang, Daniel Karcher and Ralph Bock. Expanding the genome-targeting scope and the site selectivity of high-precision base editors.Nature Communications, 2020, 11:629.

5. Junjie Tan, Fei Zhang, Daniel Karcher and Ralph Bock. Engineering of high-precision base editors for site-specific single nucleotide replacement. Nature Communications, 2019, 10:439. 

6. Yueqin Heng, Chuanyin Wu, Yu Long, Sheng Luo, Jin Ma, Jun Chen, Jiafan Liu, Huan Zhang, Yulong Ren, Min Wang, Junjie Tan, Shanshan Zhu, Jiulin Wang, Cailin Lei, Xin Zhang, Xiuping Guo, Haiyang Wang, Zhijun Cheng, Jianmin Wan. OsALMT7 Maintains Panicle Size and Grain Yield in Rice by Mediating Malate Transport. Plant Cell, 2018, 30: 889–906.

7.  Peike Sheng, Fuqing Wu, Junjie Tan, Huan Zhang, Weiwei Ma, Liping Chen, Jiachang Wang, Jie Wang, Shanshan Zhu, Xiuping Guo, Jiulin Wang, Xin Zhang, Zhijun Cheng, Yiqun Bao, Chuanyin Wu, Xuanming Liu, Jianmin Wan. A CONSTANS-like transcriptional activator, OsCOL13, functions as a negative regulator of flowering downstream of OsphyB and upstream of Ehd1 in rice. Plant Molecular Biology, 2017, 92(1-2): 209–222. 

8.  Junjie Tan, Fuqing Wu, Jianmin Wan. Flowering time regulation by the CONSTANS-Like gene OsCOL10. Plant Signaling & Behavior, 2017, 12:1. 

9. Junjie Tan, Mingna Jin, Jiachang Wang, Fuqing Wu, Peike Sheng, Zhijun Cheng, Jiulin Wang, XiaoMing Zheng, Liping Chen, Min Wang, Shanshan Zhu, Xiuping Guo, Xin Zhang, Chunming Wang , Xuanming Liu, Haiyang Wang, Chuanyin Wu and Jianmin Wan. OsCOL10, a CO-like transcriptional regulator, negatively regulates flowering time by repressing Ehd1 and FT-like genes in rice. Plant and Cell Physiology, 2016, 57(4):798-812.

10.   Fuqing Wu*, Peike Sheng*, Junjie Tan*, Xiuling Chen, Guangwen Lu, Weiwei Ma, Yueqin Heng, Qibing Lin, Shanshan Zhu, Jiulin Wang, Jie Wang, Xiuping Guo, Xin Zhang, Cailin Lei and Jianmin Wan. Plasma membrane receptor-like kinase leaf panicle 2 acts downstream of the DROUGHT AND SALT TOLERANCE transcription factor to regulate drought sensitivity in rice. Journal of Experimental Botany, 2015, 66(1):271-281. 

11. Junjie Tan*, Zhenhua Tan*, Fuqing Wu*, Peike Sheng,Yueqin Heng, Xinhua Wang, Yulong Ren, Jiulin Wang, Xiuping Guo, Xin Zhang, Zhijun Cheng, Ling Jiang, Xuanming Liu, Haiyang Wang and Jianmin Wan. A novel chloroplast-localized pentatricopeptide repeat protein involved in splicing affects chloroplast development and abiotic stress response in rice. Molecular Plant, 2014, 7(8): 1329-49. 

12. Peike Sheng*，Junjie Tan*，Mingna Jin，Fuqing Wu, Kunneng Zhou，Weiwei Ma，Yueqin Heng，Jiulin Wang，Xiuping Guo，Xin Zhang，Zhijun Cheng，Linglong Liu， Chunming Wang, Xuanming Liu and Jianmin Wan. Albino midrib 1, encoding a putative potassium efflux antiporter, affects chloroplast development and drought tolerance in rice. Plant Cell Reports, 2014, 33(9): 1581-94. 

13. Feng Zhou, Qibing Lin, Lihong Zhu, Yulong Ren, Kunneng Zhou, Nitzan Shabek, FuqingWu, Haibin Mao,Wei Dong, Lu Gan, Weiwei Ma, He Gao, Jun Chen, Chao Yang, Dan Wang, Junjie Tan, Xin Zhang, Xiuping Guo,Jiulin Wang, Ling Jiang, Xi Liu, Weiqi Chen, Jinfang Chu, Cunyu Yan, Kotomi Ueno, Shinsaku Ito, Tadao Asami, Zhijun Cheng, JieWang, Cailin Lei, Huqu Zhai, ChuanyinWu, HaiyangWang, Ning Zheng and JianminWan. D14-SCF (D3)-dependent degradation of D53 regulates strigolactone signalling. Nature, 2013, 504(7480):406-410. 

科研项目

1. 南京农业大学高层次人才科研启动项目             2021 - 2025           主持 

2. 作物遗传与种质创新国家重点实验室自主课题   2021 - 2023           主持

3. 江苏省自然科学基金青年项目                          2022 - 2024            主持

获授权专利

1.   High-Precision Base Editors. 美国，专利号：US 2022/0154163

2.    与水稻耐逆性及水稻叶绿素含量相关的蛋白及其编码基因和应用。中国，专利号： CN201310122668.9

个人荣誉

江苏省“双创”人才（2021）

国家级青年人才（2022）

农学院英才奖励基金-优秀教师奖（2023）

南京农业大学“钟山学术骨干”（2023）